Jonathon Thomalla

Graduate Student

Biochemistry, Molecular, and Cell Biology

jt799@cornell.edu

BS in Cell & Developmental Biology, University of Rochester, 2017

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I study the oocyte-to-embryo transition called egg activation in flies and mice. In the Wolfner Lab, I am using a phosphoproteomic mass spectrometry approach to further characterize the calcium signaling and global phosphoproteomic regulation that occurs during the onset of Drosophila embryogenesis. In the Schimenti Lab, I am taking a similar approach but in mouse oocytes: currently, the very early events of mammalian embryogenesis are poorly defined, largely due to technical limitations. I will use phosphoproteomics and genetics to determine whether mammals use phosphorylation state to control embryogenesis, and whether phospho-regulation is calcium-dependent.