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Snigdha Mishra, PhD

Postdoctoral Research Associate

Department of Molecular Biology and Genetics

sm978@cornell.edu

PhD in Biological Sciences, Academy of Scientific and Innovative Research (AcSIR), India

Seminal fluid proteins (SFPs) and sperm are the two most crucial components of male ejaculate that are transferred to the female reproductive tract during the process of copulation. SFPs affect the physiology and behavior of mated females, ensuring the optimal reproductive success of its mates. These phenotypes have broadly been characterized into SHORT TERM (STR) < 24hrs and LONG TERM (LTR) >10 days.

Previous studies from our lab have outlined, set of nine SFPs that work in a complimentary LTR network. SFPs like CRISP (CG17575) and protease (seminase) facilitate the transient binding of certain lectins (CG1652/CG1656), CRISPs (Antares), endopeptidase (CG9997) and long term binding of sex peptide all along the length of transferred sperm. The SFP-sperm cross-talk regulates the storage and release of later into/ from female sperm storage organs in addition to regulating other classical phenotypes of post-mating responses.

I’m working on this project with an idea to elaborate: (i). The existing LTR network, by adding fresh probable candidates to it, and explore (ii). The possibility of any female candidate that might have an interaction with the male SFPs/ sperm during the course of their journey from males to females.